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. 2021 Apr 27;15(1):56. doi: 10.3892/br.2021.1432

Figure 4.

Figure 4

Effect of oxymatrine on the expression of AKT, PEPCK and G6Pase in the liver of type 2 diabetic rats. (A) mRNA expression levels of PEPCK and (B) G6Pase. (C) Protein expression levels of PEPCK, G6Pase, AKT and pAKT. (D) Ratio of PEPCK to β-actin. (E) Ratio of G6Pase to β-actin. (F) Ratio of pAKT to β-actin. Differences between groups were compared using a one-way ANOVA. All experiments were repeated 3 times and all data are presented as the mean ± standard deviation. ***P<0.05 vs. control; #P<0.05, ##P<0.01 vs. T2DM. T2DM, type 2 diabetes mellitus; +oxymatrine (L) type 2 diabetic rats treated with 10 mg/kg body weight oxymatrine; +oxymatrine (H) type 2 diabetic rats treated 20 mg/kg body weight oxymatrine; +Metformin, type 2 diabetic rats treated with 250 mg/kg body weight metformin; p, phospho; PEPCK, phosphoenolpyruvate carboxykinase; glucose-6-phosphatase.