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. 2021 Apr 27;15(1):56. doi: 10.3892/br.2021.1432

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Copyright: © Zhu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of oxymatrine on the expression of AKT, PEPCK and G6Pase in HepG2 cells. (A) mRNA expression levels of PEPCK and (B) G6Pase in the treated cells. (C) Protein expression of PEPCK, G6Pase, AKT and pAKT. (D) Ratio of PEPCK, (E) G6Pase and (F) pAKT to β-actin. Differences between groups were compared using a one-way ANOVA. All experiments were repeated 3 times and all data are presented as the mean ± standard deviation. ^***P<0.001 vs. control; ^#P<0.05, ^##P<0.01 vs. High Glucose. +oxymatrine (L) cells treated with 0.1 µM oxymatrine; +oxymatrine (H) cells treated with 1 µM oxymatrine; +Metformin, cells treated with 0.1 µM metformin; PEPCK, phosphoenolpyruvate carboxykinase; glucose-6-phosphatase; p, phospho.