Table 2.
Global metabolism
| CTL | OVX | OVX + Fine | |
|---|---|---|---|
| Before finerenone treatment | |||
| Body weight (g) | 30.2 ± 1.2 (n = 15) | 36.1 ± 0.8 (n = 21)*** | |
| Fasting glycaemia (mmol/L) | 6.5 ± 0.3 (n = 13) | 7.6 ± 0.3 (n = 19)* | |
| Echo‐MRI before finerenone | |||
| Body weight (g) | 28.2 ± 1.3 (n = 9) | 36.5 ± 0.8 (n = 18)*** | |
| Fat mass (%) | 15.5 ± 1.8 (n = 9) | 39.2 ± 1.0 (n = 18)*** | |
| Lean mass (%) | 81.7 ± 1.7 (n = 9) | 59.2 ± 0.9 (n = 18)*** | |
| Water in lean tissue (%) | 75.1 ± 1.6 (n = 9) | 53.2 ± 0.7 (n = 18)*** | |
| After finerenone treatment | |||
| Body weight (g) | 28.4 ± 0.8 (n = 15) | 33.4 ± 0.8 (n = 12)*** | 30.2 ± 1.1 (n = 9) † |
| Food consumption (g per 48 h) | 3.47 ± 0.66 (n = 8) | 2.94 ± 0.53 (n = 8) | 3.94 ± 0.53 (n = 8) |
| Water consumption (mL per 48 h) | 3.30 ± 0.94 (n = 8) | 3.43 ± 0.33 (n = 8) | 3.81 ± 0.52 (n = 8) |
| Leptinaemia (pg/mL) | 3.6 ± 1.1 (n = 7) | 48.5 ± 6.6 (n = 11)*** | 36.0 ± 7.6 (n = 11) |
| Plasma triglycerides (mmol/L) | 1.23 ± 0.14 (n = 6) | 1.12 ± 0.12 (n = 9) | 0.96 ± 0.13 (n = 7) |
| Plasma cholesterol (mmol/L) | 1.33 ± 0.28 (n = 6) | 1.54 ± 0.08 (n = 9) | 1.48 ± 0.18 (n = 8) |
| Fasting glycaemia (mmol/L) | 6.5 ± 0.5 (n = 15) | 7.7 ± 0.1 (n = 12) 1 | 6.5 ± 0.4 (n = 9) †† |
| Echo‐MRI after finerenone | |||
| Body weight (g) | 28.4 ± 0.8 (n = 14) | 33.4 ± 0.8 (n = 12)*** | 30.2 ± 1.1 (n = 9) † |
| Fat mass (%) | 18.6 ± 2.3 (n = 14) | 31.4 ± 1.4 (n = 12)*** | 26.3 ± 1.7 (n = 9) † |
| Lean mass (%) | 79.6 ± 2.0 (n = 14) | 66.2 ± 1.3 (n = 12)*** | 71.1 ± 1.6 (n = 9) † |
| Water in lean tissue (%) | 72.6 ± 1.9 (n = 14) | 60.4 ± 1.2 (n = 12)*** | 64.6 ± 1.5 (n = 9) † |
MRI, magnetic resonance imaging.
1
P = 0.0520.
*
P < 0.05.
**
P < 0.01.
***
P < 0.001 vs. CTL.
†
P < 0.05.
††
P < 0.05 vs. OVX.