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. 2021 Mar 30;8(3):1861–1872. doi: 10.1002/ehf2.13327

Figure 4.

Figure 4

Age‐stratified expression of phosphodiesterase 9A (PDE9A) in peripheral blood mononuclear cells (PBMNCs) from subjects without heart failure (HF) and HF with preserved ejection fraction (HFpEF) in LIFE‐Heart. PDE9A (ILMN_2306540) expression data from PBMNCs were derived from HT‐12 v4 BeadChip analysis in subjects without HF (n = 1.106) and patients with HFpEF (n = 719). PDE9A (ILMN_2306540) expression reveals an age‐dependent association with HFpEF. Younger patients with HFpEF demonstrate higher PDE9A expression in PBMNCs when compared with patients without HF, whereas older patients with HFpEF have less PDE9A expression in PBMNCs (interaction P‐value 0.003; see also Table 3).