Figure 1.

Study population flow chart. The study population, comprised 415 patients with HFrEF treated with ARNI (sacubitril/valsartan cohort), were matched to patients in a separate HF registry (STRATS‐AHF registry). ⁵ , ⁶ Patients with follow‐up echocardiography within 6 months (n = 289) and 12 months (n = 371) of ARNI treatment initiation were also matched. In the STRATS‐AHF registry, 1178 patients with HFrEF without sacubitril/valsartan treatment were identified for 1:1 propensity score matching. EF, ejection fraction; HF, heart failure; HFrEF, heart failure with reduced ejection fraction; LV, left ventricular.