Figure 2.

Trajectories of cardiac function and NT‐proBNP level in patients with HFrEF treated with sacubitril/valsartan. Serial measurements of (A) LV‐EDVi, (B) LV‐ESVi, (C) LV‐EF, (D) mitral E/e′ ratio, (E) LAVI, and (F) NT‐proBNP level are shown according to the occurrence of the study outcome (cardiovascular death or HHF). Measurements in patients without an outcome event are shown in blue dots with spline curves; those in patients with an outcome event are shown in red dots with spline curves; and those in the matched control group are shown in green dots with spline curves. EDVi, end‐diastolic volume index; EF, ejection fraction; ESVi, end‐systolic volume index; HFrEF, heart failure with reduced ejection fraction; LAVI, left atrial volume index; LV, left ventricular; NT‐proBNP, N‐terminal pro B‐type natriuretic peptide.