Figure 3.

Changes in the severity of MR. The severity of MR was assessed at baseline (before ARNI treatment) and at last echocardiography (after ARNI treatment), according to the occurrence of outcome events. In patients without an outcome event, the severity of MR was decreased after ARNI treatment, whereas the patients with an outcome event did not show reduction in MR amount. Notably, the prevalence of severe MR was further increased in patients who experienced an outcome event. MR, mitral regurgitation.