Figure 4.

Survival curves according to the achievement of LV reverse remodelling. Event‐free survival curves according to the occurrence of LV reverse remodelling (A) within 6 months and (B) 12 months of sacubitril/valsartan treatment initiation are shown. Landmark analyses counting the outcome events after the determination of LV reverse remodelling (C) within 6 months and (D) within 12 months of treatment initiation are also shown. Survival curves of patients who achieved LV reverse remodelling are shown in blue, and those without LV reverse remodelling are shown in red. The overall survival in the study population was compared to that for propensity‐score matched patients with HFrEF who were not treated with sacubitril/valsartan (green colour), identified from a separate registry (STRATS‐AHF registry). ⁵ , ⁶ CI, confidence interval; HR, hazard ratio; LV, left ventricular.