Table 3.

Diagnostic performance of circulating biomarkers and plasma levels of miR‐155 and miR‐206 in iCMP

Circulating biomarker	Youden index	AUC	Sensitivity	Specificity	PPV	NPV	Accuracy
CRP	6.30 mg/L	0.62 (0.46–0.77)	72%	38%	0.66	0.44	0.59
ESR	18.50 mm	0.58 (0.44–0.72)	73%	40%	0.56	0.57	0.56
CK‐MB	22.5 U/L	0.51 (0.34–0.67)	72%	38%	0.54	0.57	0.55
Myoglobin	251 μg/L	0.39 (0.23–0.54)	69%	24%	0.36	0.55	0.41
Troponin T	34.50 ng/L	0.51 (0.36–0.65)	73%	38%	0.55	0.57	0.43
NT‐proBNP	1076 g/mL	0.51 (0.34–0.68)	73%	29%	0.49	0.55	0.51
Lake Louis criteria	—	0.62 (0.47–0.77)	62%	63%	0.81	0.38	0.60
miR‐21	8.1	0.56 (0.43–0.69)	68%	31%	0.71	0.39	0.57
miR‐126	39.6	0.48 (0.34–0.61)	68%	35%	0.62	0.33	0.57
miR‐133a	2.8	0.57 (0.45–0.71)	68%	35%	0.63	0.35	0.58
miR‐146b	4.6	0.61 (0.49–0.73)	68%	38%	0.61	0.37	0.59
miR‐155	0.87	0.68 (0.55–0.80)	75%	42%	0.65	0.53	0.61
miR‐206	2.27	0.67 (0.55–0.79)	77%	48%	0.70	0.57	0.66

CK‐MB, creatine kinase myocardial band; CRP, C‐reactive protein; ESR, erythrocyte sedimentation rate; NT‐proBNP, N‐terminal pro‐brain natriuretic peptide.

Receiver operating characteristic curve analysis was applied. Area under the curve (AUC), sensitivity, specificity, positive predictive value (PPV), negative predicative value (NPV), and diagnostic accuracy for diagnostic confirmation of inflammatory cardiomyopathy (iCMP) were calculated.