. 2021 May 13;7(6):869–877. doi: 10.1001/jamaoncol.2021.0848

Table 2. Toxic Effects Reported Within 9 Weeks of Starting Chemotherapy.

Allocation	Randomization, No. (%)
	CHEMO-INTENSITY^a						CHEMO-BSC^a
	Level A (n = 162)		Level B (n = 162)		Level C (n = 168)		Level C (n = 18)
Max CTCAE grade (week 1-9)^b	≥2	≥3	≥2	≥3	≥2	≥3	≥2	≥3
Nausea or vomiting	47 (29)	14 (8.6)	33 (20)	8 (4.9)	29 (17)	12 (7.1)	2 (11)	0
Anorexia	45 (28)	11 (6.7)	46 (28)	14 (8.6)	32 (19)	3 (1.8)	13 (17)	0
Diarrhea	34 (21)	10 (6.2)	19 (12)	10 (6.2)	7 (4.2)	3 (1.8)	1 (5.6)	1 (5.6)
Peripheral neuropathy	24 (15)	4 (2.5)	11 (6.7)	1 (0.6)	6 (3.6)	1 (0.6)	2 (11)	0
Fatigue	86 (53)	24 (15)	72 (44)	20 (12)	67 (40)	18 (11)	6 (33)	4 (22)
Infection	7 (4.3)	4 (2.5)	15 (9.3)	9 (5.6)	5 (3.0)	1 (0.6)	0	0
Thrombosis	5 (3.1)	5 (3.1)	4 (2.5)	3 (1.9)	3 (1.8)	2 (1.2)	2 (11)	2 (11)
Any nonhematological^c	125 (77)	62 (38)	116 (72)	58 (36)	101 (60)	38 (23)	10 (56)	7 (39)
WBC/neutrophils (×10⁹/l)	10 (6.2)	1 (0.6)	3 (1.9)	0	5 (3.0)	1 (0.6)	0	0
Anaemia	26 (16)	1 (0.6)	33 (20)	6 (3.7)	22 (13)	3 (1.8)	2 (11)	0
Any hematological^d	33 (20)	3 (1.9)	36 (22)	6 (3.7)	27 (16)	4 (2.4)	2 (11)	0

Abbreviations: CTCAE, Common Terminology Criteria for Adverse Events; WBC, white blood cell count.

^{^a}

Treatment pathways are detailed in the Randomization section of Methods.

^{^b}

Maximum CTCAE grade experienced weeks 1-9 in patients receiving ≥1 cycle of their allocated chemotherapy. Individual listings are shown for more common toxic effects.

^{^c}

“Any nonhematological” is defined as any of the following: nausea, vomiting, anorexia, stomatitis, diarrhea, hand-foot syndrome, peripheral neuropathy, fatigue, infection, thrombosis, or dehydration.

^{^d}

“Any hematological” is defined as any of the following: low white blood cell count, low neutrophils/granulocytes, low platelets, or anemia.