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. 2021 Apr 23;17(7):1795–1807. doi: 10.7150/ijbs.59715

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M2Φ-Exos carry miR-370 to suppress FGF1 expression. miR-370 expression in (A) mouse lung tissues and (B) ASMCs measured by RT-qPCR. (C) Targeting mRNAs of miR-370 predicted on TargetScan, miRDB and StarBase. (D) Predicted miR-370 binding site in FGF1 (FGF1-WT) and mutant sequence (FGF1-MT). (E) Binding relationship between miR-370 and FGF1 validated through a dual luciferase assay. (F-G) FGF1 expression in mouse lung tissues determined by IHC staining. (H) Expression of mRNA of FGF1 in mouse lung tissues determined by RT-qPCR. mRNA (I) and protein (J) expression of FGF1 in ASMCs determined by RT-qPCR and Western blot, respectively. Data were expressed as mean SD from at least three independent experiments. In panels A, B, G, H and I, data were analyzed by one-way ANOVA, while data in panel E were analyzed by two-way ANOVA, followed by Tukey's multiple comparison test. **p < 0.01, ***p <0.001.