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. 2021 Apr 23;17(7):1795–1807. doi: 10.7150/ijbs.59715

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FGF1 activates the MAPK/STAT1 signaling pathway. (A) Phosphorylation levels of MAPK and STAT1 in mouse lung tissues determined by Western blot. (B) Phosphorylation levels of MAPK and STAT1 in ASMCs determined by Western blot. (C-D) Expression of p-MAPK and p-STAT1 in mouse lung tissues determined by IHC staining. (E) Nuclear translocation of p-MAPK measured by immunofluorescence staining. Data were expressed as mean SD from at least three independent experiments. In panels C and D, data were analyzed by one-way ANOVA, while data in panels E were analyzed by two-way ANOVA, followed by Tukey's multiple comparison test. **p < 0.01, ***p < 0.001.