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. 2021 Apr 12;17(7):1660–1670. doi: 10.7150/ijbs.56976

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Higher expression of CHD4 mRNA is associated with poor prognosis in CRC patients. (A-E) Patients with CRC express significantly higher CHD4 mRNA than healthy individuals (A). This tendency is observed regardless of patient ethnicity (Caucasian, African-American, and Asian) (B), histological subtypes (such as adenocarcinoma and mucinous adenocarcinoma) (C), nodal metastasis (N0 to N2) (D), and individual cancer stages (E). All patients with CRC express significantly higher level of CHD4 mRNA than healthy individuals. These data are obtained from UALCAN database in TCGA CRC cancer samples. (F) Kaplan-Meier analyses of overall survival in CRC patients from online KM plotter. Patients are stratified into 'low' and 'high' CHD4 mRNA expression based on auto select best cutoff (The highest HR value (or 1/HR in case of HR<1) in case of P = 0 in the Cox regression). *P < 0.05. HR: Hazard ratio.