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Suppression of CHD4 affects the CRC tumor cell growth and increases sensitivity to cisplatin. (A) IHC staining of CHD4 expression in shLacZ and shCHD4 tumor tissues (original 400x magnification). (B) Knockdown of CHD4 reduces the tumor growth rate. (C) Tumor size in CHD4 depleted DLD-1 tumor is significantly smaller than that in parental DLD-1 tumor. *: P < 0.05.
