Figure 5.

CHD4 plays a role in regulating drug sensitivity in CRC cells. (A) Knockdown of CHD4 in DLD-1 can increase the cytotoxicity of cisplatin. (B) AnV-PI double staining shows that cisplatin induces higher cell death rate through apoptosis in CHD4 depleted DLD-1 cells. (C) Western blot analysis shows that higher levels of cleaved Caspase3 and PARP in CHD4 depleted DLD-1 cells were treated with cisplatin. Data from three independent experiments are used for statistical analysis and * P < 0.05.