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Schematic diagram depicting the role of mitochondrial complex I inhibition in the lipid-lowing effects of BBR. BBR downregulates the hyperfunction of mitochondrial complex I induced by energy excess. Its inhibitory effect on gut leads to increased lipid excretion with reduced fatty acid uptake and lipogenesis, while the decrease of lipogenesis, fatty acid uptake and oxidation is shown in liver. These alterations by BBR ameliorate obesity, fatty liver and insulin resistance.
