Table 1.

MiRNAs that regulate lipid metabolism in nonalcoholic fatty liver disease (NAFLD).

MiRNA	Circulation level	Liver expression	Function*	Identified targets
miR-21	↑10,11	↑9,15	↑	FOXA2, FOXO1, HNF4α, STAT3, INSIG2,12 LRP6,13 Hbp1,15 PPARα16,17
miR-122	↑22,38	↑22↓23	↓25,28↑27	Agpat1, Dgat1,25 CPEB1,28 Sirt129
miR-34a	↑10,11	↑32,30	↑	Sirt1,30,31,36 HNF4α,32 PPARα30
miR-27a	↓39	↑40	↓40↑41	FAS, SCD1,40 Nrf241
miR-29a	↓42	↓43in fibrosis	↓	HMGCR,44 DNMT3b,45 CD36,43 GSK3β46
miR-132	unknown	↑47	↑	FoxO3, PTEN, Sirt1, CYP2E1, P30047
miR-125b	↑22	↑48	↓	FAS49
miR-155	unknown	↑50,51	↓	Ces3/TGH,50 LXα52
miR-192	↑11,22	↓53	↓	SREBF1,54 SCD153
miR-378	unknown	↑55,56	↑	Nrf156

* ↑: aggravating hepatic steatosis; ↓: alleviating hepatic steatosis.