Table 2.
MiRNAs that regulate insulin resistance in nonalcoholic fatty liver disease (NAFLD).
| MiRNA | Circulation level | Liver expression | Function* | Identified targets |
|---|---|---|---|---|
| miR-152 | unknown | ↓60 | ↓ | PTEN60 |
| miR-499-5p | unknown | ↓61 | ↓ | PTEN61 |
| miR-26a | unknown | ↓62 | ↓ | GSK3β, PKCδ, PKCθ, ACSL3, ACSL4, PCK1, TCF7L262 |
| miR-497 | unknown | ↑63 | ↑ | InsR63 |
| miR-15b | ↑69 | ↑64,69 | ↑ | InsR64 |
| miR-30b | ↑65 | ↑65 | ↑ | SERCA2b65 |
| miR-206 | unknown | ↓66 | ↓ | PTPN166 |
| miR-190b | unknown | ↑67 | ↑ | IGF-1, ADAMTS967 |
* ↑: aggravating insulin resistance; ↓: alleviating insulin resistance.