Figure 1.

Schematic representation of the regulation and functions of m⁶A RNA modification. The reversible m⁶A RNA modification is dynamically regulated by m⁶A methyltransferases (writers) and demethylases (erasers), and recognized binding proteins (readers). Depending on the cellular context and their position in RNAs, m⁶A is involved in a number of RNA processes including alternative splicing, RNA stability, pri-miRNA processing, RNA nuclear export, RNA decay, and translation.