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The epigenetics regulation of skeletal muscle development. The development of skeletal muscle is tightly controlled by multiple epigenetic modifications at both the DNA (e.g., histone modification and DNA methylation) and the RNA (e.g., m6A methylation, non-coding RNAs, and RNA editing) levels. The interplay between m6A and other epigenetic modifications orchestrate the expression of myogenic genes during commitment, proliferation, differentiation, and fusion of skeletal muscle.
