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. 2021 May 3;22(1):715. doi: 10.3892/etm.2021.10147

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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SGLT2 knockdown inhibits cardiac fibrosis following MI in vivo. (A) Representative photomicrographs of Masson trichrome staining of hearts of MI model rats treated with PBS, sh-NC or sh-SGLT2 (n=5, original magniﬁcation x12.5). (B) Fibrotic area was determined as the ratio of the average circumference of fibrotic scars (blue)/average inner circumference of the left ventricle (n=5). Collagen I and collagen III (C) mRNA and (D) protein expression levels in cardiac tissues (n=5). ^*P<0.05, ^**P<0.01, ^***P<0.001. SGLT2, sodium-glucose linked transporter 2; MI, myocardial infarction; sh, short hairpin RNA; NC, negative control.