Table 1.
Patient demographics and disease characteristics according to severity of anxiety symptoms at the start of vortioxetine treatment (full analysis set).
| Severity of anxiety symptoms at baseline | p value* | ||
|---|---|---|---|
| Mild/moderate (GAD-7 ⩽14) | Severe (GAD-7 ⩾15) | ||
| Demographic characteristics | |||
| Patients, n | 83 | 116 | |
| Age (years), mean ± SD | 41.3 ± 12.7 | 39.7 ± 12.5 | |
| Female, n (%) | 52 (62.7) | 86 (74.1) | |
| White, n (%) | 75 (90.4) | 113 (97.4) | |
| Time since first diagnosis of MDD (years), mean ± SD | 9.3 ± 10.3 | 7.6 ± 8.9 | |
| Vortioxetine dose (mg/day), mean ± SD | |||
| Baseline | 10.0 ± 0.00 | 9.9 ± 0.65 | |
| Week 12 | 15.4 ± 5.02 | 15.5 ± 5.15 | |
| Week 52 | 16.1 ± 4.95 | 14.2 ± 5.22 | |
| Clinical characteristics, mean ± SD score | |||
| CGI-S | 4.04 ± 0.45 | 4.17 ± 0.55 | 0.057 |
| DSST | 46.7 ± 12.0 | 46.4 ± 11.0 | 0.874 |
| PDQ-D-20 | 45.6 ± 10.7 | 52.6 ± 12.2 | <0.001 |
| QIDS-SR | 17.4 ± 2.2 | 19.1 ± 2.7 | <0.001 |
| SDS | 19.3 ± 5.5 | 22.3 ± 4.4 | <0.001 |
| WHODAS 2.0 | 18.4 ± 7.1 | 22.9 ± 7.0 | <0.001 |
| WLQ | |||
| % work productivity loss | 12.2 ± 4.2 | 14.3 ± 4.6 | 0.002 |
| Mental-interpersonal demands | 46.7 ± 18.9 | 56.6 ± 19.1 | <0.001 |
| Output demands | 48.1 ± 22.3 | 56.2 ± 24.5 | 0.017 |
| Physical demands | 25.5 ± 20.6 | 34.5 ± 22.0 | 0.005 |
| Time management | 53.8 ± 19.9 | 60.7 ± 23.4 | 0.027 |
| WPAI | |||
| % total work loss | 65.3 ± 24.3 | 70.0 ± 22.3 | 0.178 |
| Absenteeism | 18.9 ± 25.5 | 24.6 ± 30.4 | 0.162 |
| Presenteeism | 59.1 ± 23.1 | 63.2 ± 22.5 | 0.226 |
Testing differences in observed baseline scores (assuming unequal variance between anxiety symptom groups). Significant at p < 0.05 (bold).
CGI-S, Clinical Global Impressions–Severity scale (score range 1–7); DSST, Digit Symbol Substitution Test (score range 0–100); GAD-7, Generalized Anxiety Disorder 7-item (total score range 0–21); PDQ-D-20, 20-item Perceived Deficits Questionnaire-Depression (total score range 0–80); MDD, major depressive disorder; QIDS-SR, Quick Inventory of Depression Symptomatology–self report (total score range 0–27); SD, standard deviation; SDS, Sheehan Disability Scale (total score range 0–30); WHODAS, World Health Organization Disability Assessment Schedule 2.0 (total score range 0–100); WLQ, Work Limitations Questionnaire (total score range 0–25%); WPAI, Work Productivity and Activity Impairment (total score range 0–100%).