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. 2021 May 2;22(1):706. doi: 10.3892/etm.2021.10138

Figure 2.

Figure 2

Effect of TGs and FFAs on the insulin signalling pathway. Elevated TG levels increase FFAs, which leads to accumulation of DAG and fatty acyl Co-A along with increased ROS. All of this together activates PKC, which interrupts the insulin signalling pathway (schematic created with BioRender.com). IRS, insulin receptor substrate; AS160, Akt substrate of 160 kDa; Glut-4, glucose transporter 4; FFA, free fatty acid; ROS, reactive oxygen species; P, phosphate; PKC, protein kinase C; DAG, diacylglycerol; Co-A, coenzyme A; FFA, free fatty acid.