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SHH, Gli1, HIP and inflammatory mediator mRNA expression in the three groups. (A) SHH, Gli1 and HIP mRNA expression levels. (B) ICAM-1, IL-6, IL-8 and TNF-α mRNA expression levels. *P<0.05 vs. control; #P<0.05 vs. CS. CS, cigarette smoke; CSC, CS + cyclopamine; Gli1, glioma-associated oncogene homolog 1; HIP, hedgehog-interacting protein; ICAM-1, intracellular adhesion molecule-1; SHH, sonic hedgehog.
