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. 2021 May 3;22(1):711. doi: 10.3892/etm.2021.10143

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Transplantation of STAT3-RNAi-transfected NSCs enhances functional recovery following SCI. (A) Images showing hindlimb movements in the sham, SCI, LC and LS groups. Red arrows indicate weight-supported stepping. (B) BBB scores in the sham, SCI, LC and LS groups. (C) Electrophysiological outcomes of the SCEP recordings at 8th week after SCI. Amplitude: The magnitude of the voltage from each group of peaks to each group of baselines. Latency: The period of time from the start of the stimulation to the appearance of the peak. Quantification of the (D) latency and (E) amplitude of the SCEP. ^*P<0.05 vs. SHAM; ^#P<0.05 vs. LC. RNAi, RNA interference; NSCs, neural stem cells; SCI, spinal cord injury; BBB, Basso, Beattie, Bresnahan; SCEP, spinal cord-evoked potential; SHAM, rats without transfection of the spinal cord; SCI, rats with complete transection of the spinal cord; LC, LV-control shRNA-transfected NSCs were injected into rats with SCI; LS, LV-STAT3 shRNA-transfected NSCs were injected into rats with SCI.