Table V.
Univariate and multivariate analysis of the influence of variables on OS and PFS.
| OS | PFS | |||||||
|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | |||||
| Variable | χ2 | P-value | HR (95% CI) | P-value | χ2 | P-value | HR (95% CI) | P-value |
| Sex (female vs. male) | 2.146 | 0.143 | - | - | 1.762 | 0.184 | - | - |
| Age (≥60 years vs. <60 years) | 0.679 | 0.410 | - | - | 0.247 | 0.619 | - | - |
| Ethnicity (Han vs. Kazakh) | 0.384 | 0.535 | - | - | 0.015 | 0.903 | - | - |
| Tumor location (Up vs. M vs. L) | 0.271 | 0.873 | - | - | 0.771 | 0.680 | - | - |
| Tumor size (≥3 cm vs. <3 cm) | 3.826 | 0.050 | - | - | 4.432 | 0.035 | 1.327 (0.942-1.870) | 0.106 |
| Degree of differentiation (PD vs. MD vs. WD) | 7.398 | 0.025 | PD 0.245 (0.072-0.841) | 0.025 | 12.282 | 0.002 | PD 0.106 (0.020-0.548) | 0.007 |
| Depth of invasion (MA vs. MS vs. FT) | 2.400 | 0.301 | - | - | 3.346 | 0.188 | - | - |
| TNM stage (I vs. II vs. III vs. IV) | 15.350 | 0.002 | - | - | 15.805 | 0.001 | - | - |
| Lymph node metastasis (yes vs. no) | 8.707 | 0.003 | 1.085 (0.716-1.642) | 0.701 | 17.046 | <0.001 | 1.479 (0.968-2.259) | 0.071 |
| Vascular invasion (yes vs. no) | 0.924 | 0.337 | - | - | 1.187 | 0.276 | - | - |
| Nerve invasion (yes vs. no) | 6.720 | 0.010 | 1.451 (1.012-2.079) | 0.043 | 4.938 | 0.026 | 1.465 (1.029-2.087) | 0.034 |
| Postradiochemotherapy (yes vs. no) | 0.003 | 0.953 | - | - | 0.224 | 0.636 | - | - |
| Hematogenous metastasis (yes vs. no) | 1.425 | 0.433 | - | - | 3.952 | 0.047 | 1.485 (0.995-2.217) | 0.053 |
| MTA1 expression (positive vs. negative) | 5.229 | 0.022 | 1.565 (0.355-0.899) | 0.016 | 2.004 | 0.157 | - | - |
| SOX4 expression (positive vs. negative) | 0.013 | 0.908 | - | - | 0.006 | 0.941 | - | - |
| EZH2 expression (positive vs. negative) | 0.807 | 0.369 | - | - | 0.657 | 0.481 | - | - |
MTA1, metastasis-associated protein 1; EZH2, enhancer of zeste homolog 2; HR, hazard ratio; PD, poorly differentiated; MD, moderately differentiated; WD, well differentiated; OS, overall survival; PFS, progression-free survival; up, upper; M, middle; L, lower; MA, mucosa; MS, muscularis; FT, full thickness.