Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 22;162(6):1816–1827. doi: 10.1097/j.pain.0000000000002169

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain.

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 4. — Behavior studies on Sox10-DTA mice after hydroxy tamoxifen (OH-Tx) painting. (A) Behavioral response to mechanical stimuli using von Frey filaments in Sox10Cre^ERT2/+ and Sox10Cre^ERT2/+; R26R^DTA/DTA mice with vehicle and OH-Tx treatments at day 0 (Baseline), day 7, and day 35 (n = 4/group) mice. There was only significant difference observed in Sox10Cre^ERT2/+; R26R^DTA/DTA (Sox10CreERT2DTA) mice treated with OH-Tx. Tukey multiple comparisons test. P = 0.001 (***) day 7 vs day 35 compared to vehicle treatment on day 7 ** P = 0.0132, 2-tailed Wilcoxon matched-pairs signed rank test. Data are presented as mean ± standard error of the mean (SEM). (B) Behavioral response to cold stimuli using acetone evaporation test score in Sox10Cre^ERT2/+ and Sox10Cre^ERT2/+; R26R^DTA/DTA mice with vehicle and OH-Tx treatments at day 0 (Baseline), day 7 and day 35 (n = 4/group) mice. There was only significant difference observed in Sox10Cre^ERT2/+; R26R^DTA/DTA mice treated with OH-Tx. Tukey multiple comparisons test. P = 0.0255 (*) Baseline vs day 7 and P = 0.0174 (*) day 7 vs day 35. Data are presented as mean ± SEM. (C) Withdrawal latency to radiant heat (Hargreaves assay) in Sox10Cre^ERT2/+ and Sox10Cre^ERT2/+; R26R^DTA/DTA mice with vehicle and OH-Tx treatments at day 0 (Baseline), day 7, and day 35 (n = 4/group) mice. There was only significant difference observed in Sox10Cre^ERT2/+; R26R^DTA/DTA mice treated with OH-Tx. Tukey multiple comparisons test. P = 0.0489 (*) day 7 vs day 35. Data are presented as mean ± SEM. (D) Behavioral response to pinprick in Sox10Cre^ERT2/+ and Sox10Cre^ERT2/+; R26R^DTA/DTA mice with vehicle and OH-Tx treatments at day 0 (Baseline), day 7, and day 35 (n = 4/group) mice. There was only significant difference observed in Sox10Cre^ERT2/+; R26R^DTA/DTA mice treated with OH-Tx. Tukey multiple comparisons test. P = 0.0121 (*) Baseline vs day 7 and P = 0.0036 (**) day 7 vs day 35. Data are presented as mean ± SEM.