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Antiviral peptides mechanisms of action against coronaviruses. A) Antiviral peptides blocking the HR1 and HR2 from forming a fusion-active core, thus preventing the viral and cellular membrane fusion. For simplicity, only one monomer is represented. B) Interaction of cationic amphipatic peptide can produce viral membrane disturbance and pore formation. C) Inhibition of viral entry with peptides that interrupt the recpetor binding, like the RBD –ACE2 interaction in coronavirus infection.
