Fig. 3.

a) Partial amino acid sequence of the surface glycoprotein of SARS-CoV-2 [ID: YP_009724390.1], where the fusion core regions of HR1 and HR2 are underlined and the candidate sequences for antiviral peptides HR1-P, HR2-P and HR2-antiP are colored. It is believed that, as it occurred in SARS-CoV, HR2-like peptide would competitively inhibits the binding of the HR2 domain to the HR1 domain, thus blocking the formation of viral fusion core, while HR1-like peptide would probably be less efficient in preventing HR1 and HR2 binding. Adapted from [33]. b) The SARS-CoV-2 S protein structure simulated by SWISS-MODEL.