Table 1.
Some examples of non-specific designed peptides that act as antivirals against enveloped viruses.
| Peptide | Sequence | Target Virus | Mechanism proposed | Reference |
|---|---|---|---|---|
| LL-37 | LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES | VEEV | Entry inhibition, Immunomodulator | [54] |
| Melitin | GIGAVLKVLTTGLPALISWIKRKRQQ | VJ | ND | [58] |
| Cecropin A | KWKLFKKIEKVGQNIRDGIIKAGPAVAVVGQATQIAK | VJ | Inhibition at late stages of virus multiplication cycle | [58] |
| Indolicidin | ILPWKWPWWPWRR | VJ | ND | [58] |
| AMLs | Lipopeptides produces from B. subtilis fmbj that included surfactin, fengycin and their isoforms | NDV | Interaction with the viral membrane | [75] |
| SIAMP | Multi peptide preparation from swine small intestines | IBV | block attachment and replication of the virus | [77] |
| Bursin | LHG | ALV | block attachment to the host cells | [81] |
| Bovine lactoferrin | CTISQPEWFKCRRWQWRMKKLGAPSITCVRRAFALECIRAIAEKKADAVTLDGGMVFEACRDPYKLRPVAAEIYGTKESPQTHYYAVAVVKKGSNFQLDQLQGRKSCHTGLGRSAGWIIPMGILRPYLSWTESLEPLQGAVAKFFSASCVPCIDRQAYPNLCQLCKGEGENQCACSSREPYFGYSGAFKCLQDGAGDVAFVKETTVFENLPEKADRDQYELLCLNNSRAPVDAFKECHLAQVPSHAVVARSVDGKEDLIWKLLSKAQEKFGKNKSRSFQLFGSPPGQRDLLFKDSALGFLRIPSKVDSALYLGSRYLTTLKNLRETAEEVKARYTRVVWCAVGPEEQKKCQQWSQQSGQNVTCATASTTDDCIVLVLKGEADALNLDGGYIYTAGKCGLVPVLAENRKSSKHSSLDCVLRPTEGYLAVAVVKKANEGLTWNSLKDKKSCHTAVDRTAGWNIPMGLIVNQTGSCAFDEFFSQSCAPGADPKSRLCALCAGDDQGLDKCVPNSKEKYYGYTGAFRCLAEDVGDVAFVKNDTVWENTNGESTADWAKNLNREDFRLLCLDGTRKPVTEAQSCHLAVAPNHAVVSRSDRAAHVKQVLLHQQALFGKNGKNCPDKFCLFKSETKNLLFNDNTECLAKLGGRPTYEEYLGTEYVTAIANLKKCSTSPLLEACAFLTR | BVDV | Prevents viral infection at its early stage | [96] |
| Chicken egg lysozyme | MRSLLILVLCFLPLAALGKVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL | BVDV | ND | [96] |
| Nisin | ITSISLCTPGCKTGALMGCNMKTATCHCSIHVSK | BVDV | ND | [96] |
ND: not determined.