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. 2021 May 13;19:209. doi: 10.1186/s12967-021-02879-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Low expression level of METTL13 is associated with poor prognosis of ccRCCs. a, b METTL13 expression levels in ccRCC tissues and normal kidney tissues according to TCGA database (a) and GSE53757 dataset (b). c, d Expression levels of METTL13 in ccRCC tissues of different tumor grades (c) and of different cancer stages (d) in TCGA dataset. e Kaplan–Meier analysis of ccRCC patients’ overall survival based on METTL13 expression in TCGA database. f, g Relative mRNA levels of METTL13 in 50 ccRCC tissues and their corresponding adjacent normal kidney tissues detected by qRT-PCR assay. h METTL13 protein levels in 13 pairs of ccRCC tumors (T) and their corresponding adjacent normal kidney tissues (N) tested by western blotting. i IHC staining of METTL13 in ccRCC tissues of different pathological grades. Mann-Whitney U-test was performed for statistical analysis for qRT-PCR and western blotting results. **P < 0.01