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. 2021 May 14;40:168. doi: 10.1186/s13046-021-01933-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — SLC6A8 expression is upregulated in TNBC tissues and associated with TNBC clinical progression. a Analysis of Slc6a8 expression in human breast cancers by tumor subtype based on data obtained from TCGA database (Normal, n = 112; Luminal, n = 815; HER2, n = 36; Basal-like TNBC, n = 114). b Slc6a8 mRNA expression was detected by qRT-PCR in human breast cancer tissues and normal counterparts (Normal, n = 60; Luminal, n = 67; HER2, n = 22; Basal-like TNBC, n = 60). c Kaplan-Meier survival analysis of the relationship between Slc6a8 expression and overall survival of TNBC patients based on TCGA data. d The ROC curve indicated the diagnostic value of SLC6A8 for TNBC. e Representative images of SLC6A8 abundances in adjacent non-cancerous tissues and TNBC tissues of different histopathological grades (Scale bars, 100 μm). f Analysis of the ratio of low or high SLC6A8 protein levels according to histological grades of 60 TNBC samples. (^*P < 0.05, ^***P < 0.001)