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. 2021 May 14;40:168. doi: 10.1186/s13046-021-01933-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — SLC6A8-mediated creatine accumulation promotes TNBC cell survival under hypoxia. shNC and shSlc6a8 TNBC cells were treated with or without 5 mM creatine (Cr) and exposed to normoxia or hypoxia for 24 h, then cell viability and apoptosis were assessed. a Cell viability was determined by CCK8 assay. b, c Cell apoptotic rate was determined using Annexin V/PI double staining. d The levels of Ki-67, Bcl-2, Bax and cleaved Caspase-3 (cleaved CASP3) were detected by western blot. Data were presented as mean ± SD (^*P < 0.05, ^**P < 0.01)