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. 2021 May 14;40:168. doi: 10.1186/s13046-021-01933-7

Fig. 7.

Fig. 7

The enhanced creatine promotes hypoxic TNBC survival via attenuation of ROS-depended repression of AKT-ERK1/2 signaling. a Ki-67, Bcl-2, Bax and cleaved Caspase-3 (cleaved CASP3) protein levels were detected by western blot in hypoxic TNBC cells supplemented with creatine or NAC. b p-ERK, ERK, p-AKT and AKT protein levels were determined by western blot in hypoxic TNBC cells supplemented with creatine or NAC. c p-ERK, ERK, p-AKT and AKT protein levels were detected by western blot in hypoxic TNBC cells under treatment with creatine alone or combined with AKT inhibitor AZD5363. d Ki-67, Bcl-2, Bax and cleaved Caspase-3 (cleaved CASP3) protein levels were determined by western blot in hypoxic TNBC cells treated the same as e. Data were presented as mean ± SD (*P < 0.05, **P < 0.01)