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. 2021 May 14;40:168. doi: 10.1186/s13046-021-01933-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Enhanced creatine promotes tumorigenesis and attenuates oxidative stress in vivo. a Photos of the xenograft tumors. b Orthotopic tumor growth curve measured on a weekly basis. c The average tumor weight of each group was shown. d Average creatine concentrations of xenograft tumors. e Relative ROS levels were detected in tumor tissues by DCFH-DA staining. f, g SLC6A8, Ki-67, Bcl-2, Bax and cleaved Caspase-3 (cleaved CASP3) protein levels in tumor tissues were determined by western blot and IHC analysis (Scale bars, 100 μm). Data were presented as mean ± SD (^*P < 0.05, ^**P < 0.01, ^***P < 0.001)