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. 2021 May 14;2:100026. doi: 10.1016/j.crphar.2021.100026

Table 2.

Structure and function of potential SARS-CoV-2 proteins.

Sr. No. Name of the Protein Structure model Function Experimental Structure
Host translation inhibitor nsp1
GenBank:
QHD43415_1 		Image 1 It inhibits host translation by interacting with host 40 ​S subunit in ribosomal complexes, including the 43 ​S pre-initiation complex and the non-translating 80 ​S ribosome. PDB: ​7k3n,
7k7p
1. Non-structural protein 2 (nsp2)
GenBank:
QHD43415_2 		Image 2 May play an important role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Only remote homologues were identified, no models have been built.
2. Papain-like proteinase (PLpro)
GenBank:
QHD43415_3 		Image 3 Responsible for the cleavages located at the N-terminus of the replicase polyprotein. PDB: 7KAG(range:1–111);
6W6Y(range:207–379);
6W9C(range:748–1060);
3. Non-structural protein 4 (nsp4)
GenBank:
QHD43415_4 		Image 4 It Participates in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. NA (range:NA)
Main proteinase 3CL-PRO
GenBank:
QHD43415_5 		Image 5 It cleaves the C-terminus of replicase polyprotein at 11 sites. It recognizes substrates containing the core sequence. PDB:
6LU7(range:1–306)
4. RNA-directed RNA polymerase (RdRp)
GenBank:
QHD43415_11 		Image 6 It Responsible for replication and transcription of the viral RNA genome. PDB:
6M71(range:1–932);
5. Helicase (Hel).
GenBank:
QHD43415_12 		Image 7 It's a Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5′ to 3′ polarity. PDB:
5RL9(range:1–601);
6. Surface glycoprotein (Spike)
GenBank:
QHD43416 		Image 8 S1 (13–685): attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. S2 (686–1273): mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. PDB:
6VYB (open state) (range:1–1273);
6VXX (closed state) (range:1–1273);
6LXT(range:912–988,1164-1202);
7. Envelope Small Membrane Protein
GenBank:
QHD43418 		Image 9 It Plays a central role in virus morphogenesis and assembly. It also plays a role in the induction of apoptosis PDB:
7K3G(range:8–39)
8. Membrane Glycoprotein
GenBank:
QHD43419 		Image 10 It's a component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins. NA(range:NA)
9. ORF7a protein (ORF7a)
GenBank:
QHD43421 		Image 11 It Plays a role as antagonist of host tetherin (BST2), disrupting its antiviral effect. PDB: ​6w37, ​7ci3