TABLE 1.
Effect of RUP with or without wortmannin on HWI electrocardiographic and echocardiographic parameters as well as serum BNP level in ISO-induced HF in rats.
| Normal | ISO | ISO/Rup | ISO/Rup/Wor | |
|---|---|---|---|---|
| HWI (mg/g) | 2.74 ± 0.07 | 3.71 ± 0.14 a | 2.74 ± 0.11 b | 3.68 ± 0.11 a,c |
| HR (bpm) | 453.8 ± 15.5 | 349.8 ± 9.5 a | 451 ± 8.2 b | 372.7 ± 29 a,c |
| QT (ms) | 81.3 ± 5.3 | 127.3 ± 10.1 a | 76 ± 5.2 b | 113.3 ± 11.2 c |
| QRS (ms) | 12.6 ± 1.9 | 25.6 ± 1.5 a | 10 ± 0.7 b | 12.7 ± 1.5 b |
| LVESD (mm) | 5.3 ± 0.05 | 8.9 ± 0.07 a | 6.5 ± 0.06 a,b | 8.5 ± 0.05 a,b,c |
| LVEDD (mm) | 7.8 ± 0.08 | 10.1 ± 0.06 a | 8.2 ± 0.09 a,b | 9.8 ± 0.04 a,b,c |
| EF (%) | 65.0 ± 1.0 | 31.6 ± 1.2 a | 60.3 ± 0.6 a,b | 52.7 ± 1.2 a,b,c |
| BNP | 115.5 ± 1.88 | 301.7 ± 24.8 a | 188 ± 3.56 a,b | 272.8 ± 20.77 a,c |
Each value represents the mean of six experiments ±SD. Statistical analysis was done using One way ANOVA followed by Tukey’s post-hoc test.
a
p <0.05 vs. normal.
b
p <0.05 vs. ISO.
c
p <0.05 vs. RUP.
BNP, brain natriuretic peptide; EF, ejection fraction; HR, heart rate; HW, heart weight; HWI, heart weight index; ISO, isoproterenol; LVESD, left ventricular end systolic diameter; LVEDD, left ventricular end diastolic diameter; Rup, rupatadine; Wor, wortmannin.