| Fentanyl compared to remifentanil for neonates receiving mechanical ventilation |
|
Patient or population: neonates receiving mechanical ventilation
Setting: one study conducted in Germany (Welzing 2012); none of the outcomes of this review were reported
Intervention: fentanyl
Comparison: remifentanil |
| Outcomes |
Anticipated absolute effects* (95% CI) |
Relative effect
(95% CI) |
№. of participants
(studies) |
Certainty of the evidence
(GRADE) |
Comments |
| Risk with remifentanil |
Risk with fentanyl |
| Pain (PIPP) |
See comment |
See comment |
Not estimable |
Not reported |
Not estimable |
None of the studies reported on this outcome |
| Duration of mechanical ventilation (days) |
See comment |
See comment |
Not estimable |
Not reported |
Not estimable |
None of the studies reported on this outcome |
| Neonatal mortality |
See comment |
See comment |
Not estimable |
Not reported |
Not estimable |
None of the studies reported on this outcome |
| Mortality before discharge |
See comment |
See comment |
Not estimable |
Not reported |
Not estimable |
None of the studies reported on this outcome |
| Neurodevelopmental outcomes (18 to 24 months) |
See comment |
See comment |
Not estimable |
Not reported |
Not estimable |
None of the studies reported on this outcome |
| Neurodevelopmental outcomes (3 to 5 years) |
See comment |
See comment |
Not estimable |
Not reported |
Not estimable |
None of the studies reported on this outcome |
| Neurodevelopmental outcomes (5 to 6 years) |
See comment |
See comment |
Not estimable |
Not reported |
Not estimable |
None of the studies reported on this outcome |
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: confidence interval; PIPP: Premature Infant Pain Profile. |
|
GRADE Working Group grades of evidence.
High certainty: we are very confident that the true effect lies close to that of the estimate of the effect.
Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.
Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect.
Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. |
