Comparison 2. Morphine compared to midazolam.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 Pain (PIPP)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.2 Pain (COMFORTneo)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.3 Duration of ventilation (days)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.4 Neonatal mortality	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.5 Weight gain at discharge (g/kg per day)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.6 Days to reach full enteral feeding	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.7 Length of stay in hospital (days)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
2.8 Any intraventricular haemorrhage (IVH)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.9 Severe intraventricular haemorrhage (Papile grade 3/4)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.10 Periventricular leukomalacia (PVL)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only