Pavey 2015.

Study name	Assessing the effectiveness of High Intensity Interval Training (HIIT) for smoking cessation in women: HIIT to quit study
Methods	A 2‐arm, parallel‐group, randomised controlled trial comparing the effects of 2 exercise interventions (HIIT and '10,000 steps' pedometer‐based intervention) combined with usual care smoking‐cessation support, on cessation rates in women who smoke and wish to quit. Blinding/masking: single (outcome assessor will be blinded to group allocations) Randomisation: allocation sequence generated by a computer programme and concealed within sealed opaque envelopes
Participants	General population: women aged 18 ‐ 55 years who smoke ≥ 5 cigarettes/day, and want to quit smoking
Interventions	Participants in both groups receive usual care smoking‐cessation support based on Smoking Cessation Guidelines for Australian General Practice (quit pack, signposting to other resources, directed to call Quitline). A) 10,000 steps: participants will receive a resource pack and pedometer, and will be asked to use the 10,000 steps log book to record steps and other physical activities. The aim will be to increase daily steps to 10,000 steps/day B) HIIT group: participants will complete 2 gym‐based supervised HIIT sessions/week and 1 home‐based HIIT session/week. At each training session participants will be asked to complete four 4‐min (4 × 4‐min) intervals at approximately 90% of maximum heart rate interspersed with 3‐min recovery periods
Outcomes	Primary outcome: % of participants who have ceased smoking using the Russell standard self‐reported abstinence (previous 2 weeks) and CO concentration < 10 ppm. Time points: 13 and 26 weeks after randomisation. Secondary outcome(s): number of cigarettes smoked on a daily basis (baseline, 13 and 26 weeks); withdrawal symptoms and cravings assessed using the Moods and Physical Symptoms Scale (MPSS; weeks 3, 6, 9 and 12); smoking dependency (FTND; baseline, weeks 6, 13 and 26); subjective stress (PSS; weeks 3, 6, 9 and 12); well‐being (SF36; baseline, 13 and 26 weeks); motivation assessed using the Behavioural Regulation in Exercise Questionnaire (BREQ‐2; baseline, 13 and 26 weeks); Cardiorespiratory fitness (VO2max) will be assessed using a graded exercise test to exhaustion; lung function will be assessed by forced vital capacity [FVC], forced expiratory volume in 1 sec [FEV1] and FEV1/FVC ratio, using a Vitalograph (2150, Ennis, Ireland); body composition will be assessed by researcher‐measured body mass index (height, weight), and waist circumference; physical activity and sedentary time will be measured using a wrist‐worn GENEActiv accelerometer, which will be worn for 1 week at each measurement time
Starting date	Date of first enrolment 10 December 2014, last enrolment 30 March 2016, date of last data collection 3 October 2016
Contact information	Dr Toby Pavey. Address: School of Human Movement Studies, Blair Drive, The University of Queensland, St. Lucia Campus, Brisbane, Australia, QLD 4072 Country Australia. Phone: +61 7 3346 9898. Email: t.pavey@uq.edu.au
Notes	Registry ID: ACTRN12614001255673 Funding source: This study is supported by a Heart Foundation of Australia Vanguard Grant (#100587). TP is supported by a National Health and Medical Research Council program grant (#569940) at The University of Queensland, School of Human Movement and Nutrition Sciences Declaration of interests: The authors declare that they have no competing interests