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. 2021 May 11;59(1):39. doi: 10.3892/ijo.2021.5219

Figure 3.

Figure 3

miR-198 upregulation inhibits OSCC cell invasion and epithelial-mesenchymal transition. OSCC cells were transfected with miR-198 mimics or NC. (A) Cell invasion was determined using a Transwell assay. Scale bar, 100 µm. The overexpression of miR-198 significantly increased the expression of E-cadherin, while decreasing the expression of N-cadherin, vimentin, MMP-2 and MMP-9 in (B) Cal-27 and (C) SCC-9 cells. (D) Levels of MMP-2 and MMP-9 in the culture supernatants were detected using ELISA. *P<0.05, **P<0.01 vs. miR-NC group. miR, microRNA; OSCC, oral squamous cell carcinoma; NC, negative control.