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. 2021 Apr 23;9:668309. doi: 10.3389/fcell.2021.668309

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Copyright © 2021 Li and Engebrecht.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary of meiotic functions of BRCA1-BARD1 in mouse and C. elegans. BRCA1-BARD1 is critical for meiotic sex chromosome inactivation (MSCI) and meiotic silencing of unsynapsed chromatin (MUSC) during mouse meiosis while it remains an open question as to whether it functions in meiotic recombination and crossover regulation. In contrast to mouse, C. elegans BRC-1-BRD-1 is dispensable for MSCI but functions in DNA end resection, inter-sister recombinational repair, RAD-51 filament stabilization and regulation of the crossover landscape.