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. 2021 Apr 23;9:668309. doi: 10.3389/fcell.2021.668309

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Copyright © 2021 Li and Engebrecht.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Conserved and non-conserved roles of BRCA2 during meiosis. BRCA2 is an essential mediator of homologous recombination in meiosis. After SPO-11 induced DSB is resected, the 3′ ssDNA is coated with RPA. BRCA2 is critical for recruiting DMC1/RAD51 recombinases to displace RPA molecules on the ssDNA, promoting the formation and stabilization of nucleoprotein filaments to mediate homology search and strand exchange. This function of BRCA2 is highly conserved during meiosis among a large variety of organisms, including C. elegans. However, C. elegans BRC-2 also exhibits a non-conserved role in promoting single strand annealing when HR (rad-51 mutant) and NHEJ (lig-4 knock down) are not available for repair (Martin et al., 2005).