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. 2021 Mar 15;162(6):bqab041. doi: 10.1210/endocr/bqab041

Figure 5.

Figure 5.

Propylparaben disrupts expression of several, but not all, ER-mediated targets. A, Relative mRNA expression of AREG mRNA. Neither parity nor propylparaben had an effect on ARexpression. B, A trend toward treatment-related effects was observed on relative mRNA expression of Igf1 mRNA (ANOVA, P = 0.078). The results are consistent with a reduction in mean Igf1 expression in parous controls compared to nulliparous females and somewhat higher expression in the PP groups. Different letters indicate P < 0.05, Fisher LSD post hoc test. C, Quantification of Wnt5a protein expression revealed no effect of parity or propylparaben exposure. D, Relative expression of TGFβ2 mRNA revealed a trend toward treatment-related effects (ANOVA, P = 0.057). TGFβ2 expression was increased in the 20PP and 10 000PP groups compared with the nulliparous controls. Different letters indicate P < 0.05, Fisher LSD post hoc test. All qRT-PCR expression data were normalized using the ΔΔCt method.