TABLE 2.
Baseline Admission Characteristics of Each Inflammation Phenotype
| Cohort Characteristics | Overall (n = 401) | Confirmed Thrombocytopenia Associated MOFa | P | Confirmed Sequential Liver Failure Associated MOFa | P | Confirmed Immunoparalysis Associated MOFa | P | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Not Confirmed (n = 364) | Confirmed (n = 37) | Not Confirmed (n = 394) | Confirmed (n = 7) | Not Confirmed (n = 316) | Confirmed (n = 85) | |||||
| Age | 0.042b | 0.716b | 0.002b | |||||||
| Median | 5.6 | 5.5 | 7.9 | 5.6 | 5.5 | 5.0 | 7.7 | |||
| (Q1–Q3) | (1.4–12.3) | (1.3–11.9) | (2.7–15.0) | (1.4–12.3) | (2.3–15.6) | (1.0–11.7) | (3.2–14.0) | |||
| Race, n (%) | 0.051c | 1.000c | 0.233c | |||||||
| White | 270 (67) | 245 (67) | 25 (68) | 264 (67) | 6 (86) | 210 (66) | 60 (71) | |||
| Black or African American | 83 (21) | 77 (21) | 6 (16) | 82 (21) | 1 (14) | 72 (23) | 11 (13) | |||
| Multiracial | 3 (1) | 1 (0) | 2 (5) | 3 (1) | 0 (0) | 2 (1) | 1 (1) | |||
| Other | 19 (5) | 18 (5) | 1 (3) | 19 (5) | 0 (0) | 15 (5) | 4 (5) | |||
| Unknown or not reported | 26 (6) | 23 (6) | 3 (8) | 26 (7) | 0 (0) | 17 (5) | 9 (11) | |||
| Ethnicity, n (%) | 0.363c | 0.341c | 0.869c | |||||||
| Unknown or not reported | 14 (3) | 14 (4) | 0 (0) | 14 (4) | 0 (0) | 11 (3) | 3 (4) | |||
| Hispanic or Latino | 66 (16) | 62 (17) | 4 (11) | 64 (16) | 2 (29) | 53 (17) | 13 (15) | |||
| Not Hispanic or Latino | 321 (80) | 288 (79) | 33 (89) | 316 (80) | 5 (71) | 252 (80) | 69 (81) | |||
| Total Pediatric Risk of Mortality score | 0.005b | 0.937b | 0.004b | |||||||
| Median | 8.0 | 7.0 | 12.0 | 8.0 | 10.0 | 7.0 | 10.0 | |||
| (Q1–Q3) | (3.0–14.0) | (3.0–14.0) | (8.0–17.0) | (3.0–14.0) | (0.0–19.0) | (3.0–13.0) | (6.0–16.0) | |||
| Malignancy at ICU admission, n (%) | 49 (12) | 39 (11) | 10 (27) | 0.008c | 47 (12) | 2 (29) | 0.206c | 29 (9) | 20 (24) | 0.001c |
| Solid organ transplant, n (%) | 8 (2) | 6 (2) | 2 (5) | 0.163c | 8 (2) | 0 (0) | 1.000c | 4 (1) | 4 (5) | 0.066c |
| Infections at eligibilityd, n (%) | ||||||||||
| Bacterial | 141 (35) | 126 (35) | 15 (41) | 0.244c | 138 (35) | 3 (43) | 1.000c | 103 (33) | 38 (45) | 0.061c |
| Fungal | 4 (1) | 1 (0) | 3 (8) | 0.285c | 4 (1) | 0 (0) | 1.000c | 1 (0) | 3 (4) | 0.285c |
| Protozoal | 1 (0) | 1 (0) | 0 (0) | 1 (0) | 0 (0) | 1 (0) | 0 (0) | |||
| Viral | 112 (28) | 100 (27) | 12 (32) | 0.459c | 111 (28) | 1 (14) | 1.000c | 92 (29) | 20 (24) | 0.561c |
MOF = multiple organ failure.
a
All subjects had at least one study blood sample collected while in the ICU.
b
Wilcoxon rank-sum test.
c
Fisher exact test.
d
Documented infections at the time of study eligibility are reported.