FIGURE 7.

Priming effects on transcriptional response to bacterial challenge. (A,C) Comparison between the cohort with Enterobacter or Serratia priming vs. the cohort with native microbiota. Plotted are genes with q-value < 0.05 in either comparison to cohort with native microbiota. Labeled genes have log₂ fold change in either comparison >2.5 or <–2.5 in (A) and >3.5 or <–3.5 in (C). The genes in quadrant I and IV were the genes differentially expressed upon different priming regimes. (B,D) Distribution of the genes that were altered by priming. Total number of altered genes is placed on top of the circle, number of up- or down-regulated genes were specified inside the circle. The genes in the central area were shared by both cohorts with respective priming.