Table 2.

Brain volume changes with age.

		Average volume (cm3)	Annual changes (cm3)	95% CI of Annual Changes	Annual changes%	R2	P	Linear regression
Cerebral parenchyma	all	1020.1±100.7	−2.59	−4.324 to −0.858	−0.24	0.17	0.004*	Y = −2.59*X + 1142.0
	male	1086.2±83.2	−3.01	−4.810 to −1.205	−0.26	0.38	0.002*	Y = −3.01*X + 1226.0
	female	959.6±74.1	−1.81	−3.765 to −0.139	−0.18	0.14	0.07	Y = −1.81*X + 1046.0
Cortical GM	all	568.6±59.1	−2.03	−2.962 to −1.095	−0.32	0.30	<0.001*	Y = −2.03*X + 663.5
	male	603.4±52.1	−2.27	−3.229 to −1.311	−0.34	0.55	<0.001*	Y = −2.27*X + 708.6
	female	535.7±45.7	−1.59	−2.687 to −0.502	−0.27	0.29	0.006*	Y = −1.59*X + 611.6
WM	all	409.3±42.9	−0.50	−1.305 to 0.288	−0.12	0.04	0.205	Y = −0.50*X + 433.2
	male	437.8±33.6	−0.67	−1.539 to 0.193	−0.15	0.12	0.12	Y = −0.67*X + 469.0
	female	383.3±33.0	−0.19	−1.124 to 0.749	−0.05	0.01	0.68	Y = −0.19*X + 392.2
Subcortical GM	all	42.7±3.6	−0.05	−0.121 to 0.012	−0.11	0.06	0.107	Y = −0.05*X + 45.3
	male	45.1±3.5	−0.06	−0.156 to 0.027	−0.13	0.10	0.16	Y = −0.06*X + 48.1
	female	40.6±2.1	−0.05	−0.105 to 0.107	−0.13	0.14	0.07	Y = −0.05*X + 38.2

Data are presented as mean ± SD. The level of significance was set as P<0.05.