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. Author manuscript; available in PMC: 2022 May 15.
Published in final edited form as: J Immunol. 2021 Apr 28;206(10):2412–2419. doi: 10.4049/jimmunol.2000865

Figure 4. Tumor-specific T cells are lost in the circulation during sepsis, but remain unchanged in tumor tissue.

Figure 4.

(A) Schematic showing the experimental design for Figure 3. LLC-OVA cancer animals were generated as previously described. CLP surgery was performed to induce polymicrobial sepsis and sham surgery was performed as a control on mice. 24 hours later, animals were sacrificed. (B) Summary graphs showing the absolute number of tumor-specific OT-I cells (gated on CD3+CD8+Thy1.1+ cells) in tumor, TDLN, and spleen. (C) Summary graphs showing the absolute number of endogenous CD8+ T cells (gated on CD3+CD8+Thy1.1- cells) in tumor, TDLN, and spleen. *p≤0.05, **p≤0.01, ***p≤0.001