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Dendritic cells (DC) are located in the lung interstitium and alveoli, where they act as sentinel cells. Any imbalance of their frequency distribution and functional status may have significant consequences in disease pathogenesis. Emerging evidence suggests that plenty of local factors along with different arrays of chemo-cytokines can modulate DCs maturation in the lung of patients affected by idiopathic pulmonary fibrosis, thus affecting their tolerogenic or immunogenic properties.
