TABLE 2.

LncRNAs in the pathogenesis of Preeclampsia.

lncRNAs	Source	Expression	Target	Function	References
AGAP2-AS1	Placental tissues	downregulated	miR-574-5p/JDP2	proliferation, invasion and apoptosis	Xu et al., 2020
ATB	Placental tissues	downregulated	-	migration, proliferation, and tube formation	Liu X. et al., 2017
CCAT1	Placental tissues	upregulated	D1-P16-CDK4	cell proliferation and cell cycle	Deng et al., 2015
DC	Dendritic cells	upregulated	p-STAT3	invasion	Zhang W. et al., 2017, 2020
EGFR-AS1	Placental tissues	downregulated	EGFR-JAK/STAT	proliferation	Zhao and Jiang, 2018
H19	Placental tissues	upregulated	PI3K/AKT/mTOR	cell viability, invasion, autophagy	Xu J. et al., 2018
	Exosomes secreted by MSCs	upregulated	microRNA let-7b/FOXO1	invasion, migration and apoptosis	Chen Y. et al., 2020
HOTAIR	Placental tissues	upregulated	miR-106a/EZH2	proliferation, migration and invasion	Zhao et al., 2020
HOTTIP	Placental tissues	downregulated	RND3	cell proliferation and cell cycle	Li et al., 2018
KCNQ1OT1	Placental tissues	downregulated	miR-146a-3p/CXCL12/CXCR4	proliferation, invasion and migration	Chen Y. et al., 2020
Linc00261	Placental tissues	upregulated	miR-558/TIMP4	invasion, migration and apoptosis	Cheng et al., 2019b
LINC00511	Placental tissues	downregulated	miR-31-5p/HOXA7	proliferation, invasion and autophagy	Dong X. et al., 2020
lncRNA uc.187	Placental tissues	upregulated	-	proliferation, invasion and apoptosis	Cao et al., 2017
lncZBTB39	Placental tissues	upregulated	miR-210/THSD7A	invasion and migration	Tian et al., 2020
MALAT1	Placental tissues	downregulated	-	proliferation, migration invasion and apoptosis	Chen H. et al., 2015
	Placental tissues	downregulated	FOS	EMT, migration and invasion	Li et al., 2020
	Placental tissues	downregulated	miR-206/IGF-1	migration and invasion	Wu et al., 2020
	Umbilical cord tissues and MSCs	downregulated	VEGF/IDO	proliferation, angiogenesis, and Immunosuppressive	Li et al., 2017a
MEG3	Placental tissues	downregulated	NF-kB, Caspase-3, and Bax	apoptosis and migration	Zhang et al., 2015; Liu W. et al., 2017
MIR503HG	Placental tissues	upregulated	NF-kB, MMP-2/-9, the snail protein, and E-cadherin	proliferation, invasion, migration, apoptosis and cell cycle	Cheng et al., 2019a
NR_002794	Placental tissues	upregulated	-	proliferation, invasion and apoptosis	Ma et al., 2019
PGK1P2	Placental tissues	downregulated	miR-330-5p	angiogenesis, glycolysis metabolism and decidualization	Tong et al., 2018
PVT1	Placental tissues	downregulated	PI3K/AKT pathway	proliferation, migration and invasion	Xu Y. et al., 2018; Wang Q. et al., 2019
RP11-465L10.10	Placental tissues	downregulated	MMP-9	invasion	Fan et al., 2016; Long et al., 2016
RPAIN	Placental tissues	upregulated	C1q	proliferation, invasion and apoptosis	Song et al., 2017
SNHG5	Placental tissues	downregulated	miR-26a-5p/N-cadherin	proliferation, migration and invasion	Yang et al., 2019
SPRY4-IT1	Placental tissues	upregulated	Wnt/β-catenin pathway	proliferation, migration and apoptosis	Zou et al., 2013, Zuo et al., 2016
Storkhead box 2	Placental tissues	upregulated	STOX2	differentiation and invasion	Oudejans et al., 2016
TCL6	Placental tissues	upregulated	PTEN	cell proliferation and cell cycle	Wu J.L. et al., 2019
TDRG1	Placental tissues	downregulated	miR-214-5p, Notch	proliferation, migration, and invasion	Gong et al., 2020b
TUG1	Placental tissues	downregulated	miR-204-5p, miR-29b/MCL1/VEGFA/MMP-2	migration, invasion, proliferation, apoptosis and angiogenesis	Yu et al., 2018; Li Q. et al., 2019
ZEB2-AS1	Placental tissues	downregulated	miR-149/PGF	proliferation, migration and invasion	Gao et al., 2019